THE HIGH AFFINITY PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND DAA1106 BINDS TO ACTIVATED AND INFECTED BRAIN MACROPHAGES IN AREAS OF SYNAPTIC DEGENERATION: IMPLICATIONS FOR PET IMAGING OF NEUROINFLAMMATION IN LENTIVIRAL ENCEPHALITIS

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated brain macrophages in HIVE.Using cell culture

Although lumbar stenosis was recognized as a contraindication for endoscopic spine surgery in the past, the advancement in endoscopic system design and development of approach techniques and strategies now enabled the endoscopic spine surgeons to manage all types of lumbar stenosis safely and more effectively.A full-endoscopic lumbar technique for

Image XYLIWHITE segmentation is a process that densely classifies image pixels into different regions corresponding to real world objects.However, this correspondence is not always exact in images since there are many uncertainty factors, e.g., recognition hesitation, imaging equipment, condition, and atmosphere environment.To achieve the segmentat

Global developmental delay (GDD) is a common neurodevelopmental disorder in children under 5 years of age.This study assessed the potential of functional Near-Infrared Spectroscopy 4 pin DIN Cable (fNIRS) technology aiding diagnosis of GDD in premature infants and explored brain pathogenesis of GDD.This prospective cohort study was conducted betwee